PARP3

Across TCGA patient cohorts, PARP3 mutation is significantly associated with the RNA expression of many other genes, with 3,837 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARP3-associated genes across cancer lineages are LARP1, MIER3, and MOCS2. Each is linked with PARP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARP3-to-partner and partner-to-PARP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LARP1 grouped by PARP3-low versus PARP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP3→partner) and Y-score (partner→PARP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LARP1 →	+0.392	+1.818	.003	.002	3	2
UCEC	MIER3 →	+0.480	+2.148	.002	<.001	3	2
UCEC	MOCS2 →	+0.436	+3.665	<.001	<.001	3	2
UCEC	NDUFAF2 →	+0.477	+3.818	.002	<.001	3	2
UCEC	NDUFB6 →	+0.395	+2.711	.003	.003	3	2
UCEC	FBXO33 →	+0.452	+2.555	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,837 associations by consensus.

LARP1 by PARP3 expression — UCEC

Explore this box plot interactively →