PARP15

Across TCGA patient cohorts, PARP15 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARP15-associated genes across cancer lineages are Caspase-7-cleavedD198, Smad1, and 14-3-3_beta. Each is linked with PARP15 in more than 3 cancer types. Because this analysis shows association rather than direction, both PARP15-to-partner and partner-to-PARP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PARP15-low versus PARP15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP15→partner) and Y-score (partner→PARP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.542	+1.926	.007	.008	3	4
UCEC	Smad1 →	+0.105	+1.700	.049	.042	3	3
UCEC	14-3-3_beta →	-0.087	-2.558	.010	.010	3	2
UCEC	Notch1 →	+0.125	+1.887	.009	.029	3	2
UCEC	PCNA →	+0.178	+2.321	.015	.033	3	2
UCEC	Cyclin-B1 →	+0.708	+2.137	<.001	.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Caspase-7-cleavedD198 by PARP15 expression — UCEC

Explore this box plot interactively →