PARP15

Across TCGA cell cohorts, PARP15 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,842 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PARP15-associated GO terms across cancer lineages are Regulation of synaptic activity, Negative regulation of syncytium formation by plasma membrane fusion, and Regulation of syncytium formation by plasma membrane fusion. Each is linked with PARP15 in more than 5 cancer types. Because this analysis shows association rather than direction, both PARP15-to-partner and partner-to-PARP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of synaptic activity grouped by PARP15-low versus PARP15-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP15→partner) and Y-score (partner→PARP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of synaptic activity →	+1.103	+2.054	<.001	<.001	3	6
BREAST	Negative regulation of syncytium formation by plasma membrane fusion →	+0.087	+0.090	<.001	.001	3	6
BREAST	Regulation of syncytium formation by plasma membrane fusion →	+0.069	+0.083	.002	.003	3	6
BREAST	Regulation of alternative mRNA splicing, via spliceosome →	+0.083	+0.081	<.001	.003	3	5
BREAST	Basement membrane disassembly →	+1.225	+0.100	<.001	.005	3	5
LUNG_NSCLC_LUAD	Positive regulation of cytoplasmic translation →	+0.076	+0.181	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,842 associations by consensus.

Regulation of synaptic activity by PARP15 expression — BLOOD_Leukemia

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