PARP15

Across TCGA cell cohorts, PARP15 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PARP15-associated genes across cancer lineages are LCE1C, LAIR2, and CCDC194. Each is linked with PARP15 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARP15-to-partner and partner-to-PARP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE1C grouped by PARP15-low versus PARP15-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP15→partner) and Y-score (partner→PARP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LCE1C →	+0.432	+4.922	.002	.009	3	2
LARGE_INTESTINE	LAIR2 →	+0.624	+3.482	.002	.008	3	1
LARGE_INTESTINE	CCDC194 →	+0.418	+3.556	.002	.007	3	1
BLOOD_Leukemia	SLC5A8 →	+0.182	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR10A6 →	+0.044	+5.201	<.001	.006	3	1
BLOOD_Leukemia	CFHR2 →	+0.395	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

LCE1C by PARP15 expression — BLOOD_Leukemia

Explore this box plot interactively →