PARP14

Across TCGA patient cohorts, PARP14 mutation is significantly associated with the RNA expression of many other genes, with 6,669 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARP14-associated genes across cancer lineages are RNA5SP412, CCDC134, and PSMA6. Each is linked with PARP14 in more than 3 cancer types. Because this analysis shows association rather than direction, both PARP14-to-partner and partner-to-PARP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by PARP14-low versus PARP14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP14→partner) and Y-score (partner→PARP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.364	+1.342	<.001	.007	3	4
UCEC	CCDC134 →	+0.478	+1.809	<.001	<.001	3	4
UCEC	PSMA6 →	+0.380	+2.271	.002	<.001	3	4
UCEC	HNRNPL →	+0.339	+1.667	<.001	<.001	3	4
COAD	TVP23B →	+0.541	+2.515	<.001	.001	3	4
UCEC	GINS3 →	+0.648	+3.158	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,669 associations by consensus.

RNA5SP412 by PARP14 expression — UCEC

Explore this box plot interactively →