PARP14

Across TCGA pan-cancer cohorts, PARP14 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated PARP14 data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PARP14 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PARP14 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, LGG, and PAAD are the cancer types where PARP14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.397	0.272	<.001	118	view →
LGG	OS	Median	All	0.359	0.533	<.001	52	view →
PAAD	OS	Quartile	All	0.354	0.716	.001	36	view →
UCEC	DFS	Quartile	All	0.773	0.885	.004	34	view →
LUSC	DFS	Median	III,IV	0.228	0.851	<.001	30	view →
HNSC	DFS	Quartile	All	0.754	0.525	<.001	29	view →
THCA	OS	Median	All	0.994	0.956	.003	29	view →
ACC	OS	Quartile	III,IV	0.111	0.668	.019	26	view →
BRCA	DFS	Quartile	III,IV	0.714	0.470	.004	24	view →
KIRP	DFS	Median	All	0.804	0.902	.006	23	view →
CESC	OS	Tertile	All	0.877	0.721	.003	22	view →
KIRC	DFS	Tertile	II,III,IV	0.651	0.348	.008	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

PARP14–SKCM (OS)

Open the SKCM breakdown →