PARP14

Across TCGA cell cohorts, PARP14 mutation is significantly associated with the RNA expression of many other genes, with 310 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PARP14-associated genes across cancer lineages are SMIM23, TEX35, and CRYGA. Each is linked with PARP14 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARP14-to-partner and partner-to-PARP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM23 grouped by PARP14-low versus PARP14-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP14→partner) and Y-score (partner→PARP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SMIM23 →	+0.023	+4.906	<.001	.006	3	2
BLOOD_Leukemia	TEX35 →	+0.147	+2.769	<.001	.003	3	2
OESOPHAGUS	CRYGA →	+0.043	+4.906	<.001	.006	3	1
OESOPHAGUS	OR6B1 →	+0.013	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	TXNDC8 →	+0.019	+5.169	<.001	.001	3	1
CNS	HES3 →	+0.030	+4.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 310 associations by consensus.

SMIM23 by PARP14 expression — OESOPHAGUS

Explore this box plot interactively →