PARP11

Across TCGA cell cohorts, PARP11 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible PARP11-associated genes across cancer lineages are ACTRT1, WFDC8, and MAGEB5. Each is linked with PARP11 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARP11-to-partner and partner-to-PARP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTRT1 grouped by PARP11-low versus PARP11-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP11→partner) and Y-score (partner→PARP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ACTRT1 →	+0.023	+4.906	<.001	.006	3	1
OESOPHAGUS	WFDC8 →	+0.020	+4.906	<.001	.006	3	1
OESOPHAGUS	MAGEB5 →	+0.040	+4.906	<.001	.006	3	1
OESOPHAGUS	OR5B21 →	+0.023	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ACTRT1 by PARP11 expression — OESOPHAGUS

Explore this box plot interactively →