PARP11-AS1

Across TCGA pan-cancer cohorts, PARP11-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PARP11-AS1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PARP11-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PARP11-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCS show a favorable association.

LUAD, KIRC, and UCS are the cancer types where PARP11-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.760	0.594	<.001	79	view →
KIRC	DFS	Median	IV	0.352	0.632	<.001	40	view →
UCS	OS	Median	IV	0.732	0.224	.018	36	view →
KICH	OS	Median	All	0.761	0.972	.009	35	view →
SKCM	OS	Tertile	All	0.818	0.710	<.001	34	view →
ESCA	OS	Quartile	III,IV	0.686	0.344	.014	26	view →
UVM	OS	Tertile	III,IV	0.304	0.805	.013	20	view →
LIHC	DFS	Median	All	0.394	0.208	.008	19	view →
BLCA	OS	Quartile	III,IV	0.678	0.375	.011	13	view →
MESO	OS	Median	III,IV	0.286	0.471	.007	11	view →
BRCA	OS	Median	All	0.622	0.530	.019	10	view →
LGG	OS	Median	All	0.925	0.863	.005	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PARP11-AS1–LUAD (OS)

Open the LUAD breakdown →