PARP11-AS1

Across TCGA pan-cancer cohorts, PARP11-AS1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PARP11-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where PARP11-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PARP11-AS1 is over-expressed in tumor, although a few such as UCEC and THCA show the opposite, repressed pattern.

UCEC, KIRC, and ESCA are the cancer types where PARP11-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PARP11-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	All	−0.160	.025	4	view →
KIRC	All	All	+0.077	.003	3	view →
ESCA	All	II,III,IV	+0.195	.037	2	view →
THCA	Male	II,III,IV	−0.184	.019	2	view →
COAD	All	II,III,IV	−0.115	.021	2	view →
CHOL	All	All	+0.191	.008	1	view →
KICH	All	IV	+0.092	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PARP11-AS1–UCEC

Open the UCEC breakdown →