PARP10

Across TCGA cell cohorts, PARP10 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,928 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PARP10-associated GO terms across cancer lineages are Antigen processing and presentation of peptide antigen via MHC class I, Protein poly-ADP-ribosylation, and Antigen processing and presentation of endogenous peptide antigen via MHC class I. Each is linked with PARP10 in more than 17 cancer types. Because this analysis shows association rather than direction, both PARP10-to-partner and partner-to-PARP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antigen processing and presentation of peptide antigen via MHC class I grouped by PARP10-low versus PARP10-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP10→partner) and Y-score (partner→PARP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Antigen processing and presentation of peptide antigen via MHC class I →	+0.218	+1.860	<.001	<.001	3	18
LIVER	Protein poly-ADP-ribosylation →	+0.239	+2.765	<.001	<.001	3	17
BREAST	Antigen processing and presentation of endogenous peptide antigen via MHC class I →	+0.297	+2.471	<.001	<.001	3	17
SOFT_TISSUE	Antigen processing and presentation of endogenous peptide antigen →	+0.280	+2.430	<.001	<.001	3	17
BREAST	Regulation of cytokine-mediated signaling pathway →	+0.070	+2.068	<.001	<.001	3	17
BREAST	Regulation of response to cytokine stimulus →	+0.065	+2.216	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,928 associations by consensus.

Antigen processing and presentation of peptide antigen via MHC class I by PARP10 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →