PARP10

Across TCGA pan-cancer cohorts, PARP10 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PARP10’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PARP10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PARP10 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where PARP10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PARP10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.306	<.001	12	view →
COAD	Female	All	+0.777	<.001	12	view →
HNSC	All	All	+0.817	<.001	11	view →
BLCA	All	All	+0.869	.002	10	view →
STAD	Male	II,III,IV	+1.414	<.001	8	view →
LIHC	Male	All	+1.148	<.001	6	view →
BRCA	All	II,III,IV	+0.543	<.001	6	view →
CHOL	All	All	+1.268	<.001	3	view →
ESCA	All	All	+1.033	.008	2	view →
READ	All	All	+0.776	<.001	2	view →
KIRP	Female	All	+0.381	.021	2	view →
KICH	All	All	−0.314	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PARP10–KIRC

Open the KIRC breakdown →