PARM1-AS1

Across TCGA pan-cancer cohorts, PARM1-AS1 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated PARM1-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PARM1-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PARM1-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

HNSC, UVM, and UCS are the cancer types where PARM1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.864	0.729	<.001	96	view →
UVM	OS	Tertile	All	0.305	0.796	.001	63	view →
UCS	DFS	Median	II,III,IV	0.530	0.157	.008	48	view →
LUAD	OS	Median	All	0.854	0.774	.003	44	view →
LUSC	DFS	Median	III,IV	0.189	0.767	.005	24	view →
KIRC	OS	Median	All	0.899	0.854	.015	19	view →
MESO	DFS	Tertile	III,IV	0.539	0.322	.017	15	view →
DLBC	DFS	Median	All	0.622	1.000	.014	14	view →
BRCA	DFS	Tertile	III,IV	0.876	0.750	.021	9	view →
THCA	OS	Tertile	All	0.992	0.996	.044	4	view →
COAD	DFS	Tertile	IV	0.542	0.348	.036	3	view →
LGG	DFS	Quartile	All	0.337	0.468	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

PARM1-AS1–HNSC (OS)

Open the HNSC breakdown →