PARM1-AS1

Across TCGA pan-cancer cohorts, PARM1-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PARM1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PARM1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PARM1-AS1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and LUAD are the cancer types where PARM1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PARM1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.248	<.001	7	view →
KIRC	All	III,IV	−0.023	<.001	7	view →
LUAD	All	III,IV	−0.168	.009	3	view →
LUSC	Male	II,III,IV	−0.119	.010	3	view →
KIRP	All	II,III,IV	−0.028	.007	3	view →
PAAD	Male	All	+0.075	.037	2	view →
BRCA	All	III,IV	−0.057	.030	2	view →
COAD	Female	All	−0.055	.024	2	view →
STAD	Female	All	+0.048	.023	2	view →
HNSC	Female	II,III,IV	−0.024	.037	2	view →
KICH	Male	III,IV	−0.032	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PARM1-AS1–THCA

Open the THCA breakdown →