PARL

Across TCGA patient cohorts, PARL protein abundance is significantly associated with the RNA expression of many other genes, with 4,477 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PARL-associated genes across cancer lineages are DVL3, TMEM41A, and ALG3. Each is linked with PARL in more than 2 cancer types. Because this analysis shows association rather than direction, both PARL-to-partner and partner-to-PARL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PARL versus DVL3 in LSCC, with a Pearson correlation of 0.68.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARL→partner) and Y-score (partner→PARL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DVL3 →	+1.419	+1.280	<.001	<.001	3	3
LSCC	TMEM41A →	+0.726	+0.690	.002	.001	3	3
LSCC	ALG3 →	+0.960	+0.820	<.001	<.001	3	3
HNSC	SMKR1 →	+1.038	+0.591	.001	.004	3	3
HNSC	DCUN1D1 →	+1.000	+0.632	.001	.004	3	3
CCRCC	JAM2 →	-0.845	-0.651	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,477 associations by consensus.

PARL vs DVL3 — LSCC

Explore this scatter interactively →