PARK7

Across TCGA cell cohorts, PARK7 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,221 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible PARK7-associated GO terms across cancer lineages are 'de novo' pyrimidine nucleobase biosynthetic process, DNA replication initiation, and Positive regulation of mitotic cell cycle phase transition. Each is linked with PARK7 in more than 10 cancer types. Because this analysis shows association rather than direction, both PARK7-to-partner and partner-to-PARK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 'de novo' pyrimidine nucleobase biosynthetic process grouped by PARK7-low versus PARK7-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PARK7→partner) and Y-score (partner→PARK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	'de novo' pyrimidine nucleobase biosynthetic process →	+0.188	+0.808	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.129	+0.762	.001	.002	3	11
PANCREAS	Positive regulation of mitotic cell cycle phase transition →	+0.111	+0.669	.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Defense response to bacterium →	-0.099	-0.719	.008	.005	3	10
LUNG_NSCLC_LUSC	Negative regulation of ubiquitin protein ligase activity →	+0.248	+1.120	.001	<.001	2	11
PANCREAS	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.087	+0.444	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,221 associations by consensus.

'de novo' pyrimidine nucleobase biosynthetic process by PARK7 expression — PANCREAS

Explore this box plot interactively →