Across TCGA patient cohorts, PARG mutation is significantly associated with the RNA expression of many other genes, with 4,416 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARG-associated genes across cancer lineages are COPS8P1, RN7SL241P, and SERINC4. Each is linked with PARG in more than 1 cancer types. Because this analysis shows association rather than direction, both PARG-to-partner and partner-to-PARG results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARG→partner) and Y-score (partner→PARG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	COPS8P1 →	+0.111	+5.355	<.001	.005	3	2
CESC	RN7SL241P →	+0.109	+4.342	<.001	.007	3	2
STAD	SERINC4 →	+0.029	+4.561	<.001	.004	3	2
STAD	MIR3689B →	+0.262	+5.226	<.001	.003	3	2
UCEC	MPI →	+0.304	+2.243	.006	.005	3	2
UCEC	GEMIN4 →	+0.398	+1.530	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,416 associations by consensus.

Exploration

PARG survival (RNA) · tumor vs normal (RNA) · all PARG data types