PARD6G

Across TCGA patient cohorts, PARD6G mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARD6G-associated genes across cancer lineages are PCNA, ATM, and TFRC. Each is linked with PARD6G in more than 2 cancer types. Because this analysis shows association rather than direction, both PARD6G-to-partner and partner-to-PARD6G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PARD6G-low versus PARD6G-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARD6G→partner) and Y-score (partner→PARD6G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.265	+2.178	.022	.035	3	3
UCEC	ATM →	-0.661	-2.906	<.001	.001	3	3
COAD	TFRC →	+0.712	+2.841	.004	.033	3	2
UCEC	EGFR_pY1068 →	-0.314	-2.222	.003	.011	3	1
UCEC	eIF4E →	+0.183	+2.820	.040	.035	3	1
UCEC	ERK2 →	+0.232	+2.459	.004	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

PCNA by PARD6G expression — COAD

Explore this box plot interactively →