PARD6G

Across TCGA pan-cancer cohorts, PARD6G RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PARD6G’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PARD6G RNA is repressed in tumor relative to normal tissue. In most cancer types PARD6G is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, KIRP, and LIHC are the cancer types where PARD6G tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PARD6G RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−1.352	<.001	11	view →
KIRP	Male	All	−1.082	<.001	9	view →
LIHC	Female	II,III,IV	+1.145	<.001	8	view →
LUSC	Female	II,III,IV	+2.340	<.001	7	view →
LUAD	All	All	+0.407	<.001	5	view →
KIRC	All	All	+0.371	.002	5	view →
BRCA	Female	All	−0.483	<.001	4	view →
CHOL	All	All	+1.376	<.001	3	view →
KICH	Female	All	−1.065	<.001	2	view →
READ	Female	All	−1.009	.036	2	view →
PRAD	All	All	−0.566	<.001	2	view →
HNSC	All	All	+0.453	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PARD6G–THCA

Open the THCA breakdown →