PARD6G

Across TCGA cell cohorts, PARD6G mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PARD6G-associated genes across cancer lineages are TEX46, IL5, and SIRPD. Each is linked with PARD6G in more than 1 cancer types. Because this analysis shows association rather than direction, both PARD6G-to-partner and partner-to-PARD6G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX46 grouped by PARD6G-low versus PARD6G-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARD6G→partner) and Y-score (partner→PARD6G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TEX46 →	+0.151	+3.497	<.001	.004	3	2
LARGE_INTESTINE	IL5 →	+0.118	+3.754	<.001	.002	3	1
LARGE_INTESTINE	SIRPD →	+0.015	+2.977	<.001	.006	3	1
LARGE_INTESTINE	CHMP7 →	+0.805	+3.064	.005	.009	3	1
LARGE_INTESTINE	SLC39A12 →	+0.056	+3.963	.004	.001	3	1
LARGE_INTESTINE	KCNK4 →	+0.038	+3.708	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

TEX46 by PARD6G expression — LARGE_INTESTINE

Explore this box plot interactively →