PARD6B

Across TCGA patient cohorts, PARD6B mutation is significantly associated with the RNA expression of many other genes, with 1,719 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARD6B-associated genes across cancer lineages are RNU6-698P, MIR2113, and MTCO1P47. Each is linked with PARD6B in more than 2 cancer types. Because this analysis shows association rather than direction, both PARD6B-to-partner and partner-to-PARD6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-698P grouped by PARD6B-low versus PARD6B-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARD6B→partner) and Y-score (partner→PARD6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNU6-698P →	+0.432	+3.194	.001	.006	3	3
KIRC	MIR2113 →	+0.204	+8.025	<.001	.007	3	3
KIRP	MTCO1P47 →	+0.181	+3.804	<.001	.009	3	2
KIRP	MTND6P25 →	+0.222	+4.226	<.001	.003	3	2
KIRP	UBTFL10 →	+0.075	+3.715	.006	.008	3	2
SKCM	OR4M1 →	+0.036	+4.513	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,719 associations by consensus.

RNU6-698P by PARD6B expression — STAD

Explore this box plot interactively →