PARD3

Across TCGA cell cohorts, PARD3 mutation is significantly associated with the RNA expression of many other genes, with 1,843 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PARD3-associated genes across cancer lineages are OR52N4, C14orf180, and GPR33. Each is linked with PARD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARD3-to-partner and partner-to-PARD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52N4 grouped by PARD3-low versus PARD3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARD3→partner) and Y-score (partner→PARD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR52N4 →	+0.017	+4.087	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	C14orf180 →	+0.006	+4.510	<.001	.003	3	2
BLOOD_Lymphoma	GPR33 →	+0.063	+3.843	.007	.007	3	2
LUNG_NSCLC_LUAD	CSH1 →	+0.063	+4.343	<.001	.002	3	2
CNS	CELA3B →	+0.182	+5.754	<.001	.002	3	2
LARGE_INTESTINE	MFSD6L →	+0.688	+1.949	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,843 associations by consensus.

OR52N4 by PARD3 expression — URINARY_TRACT

Explore this box plot interactively →