PAQR8

Across TCGA cell cohorts, PAQR8 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PAQR8-associated genes across cancer lineages are AVP, HAO2, and IL22. Each is linked with PAQR8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAQR8-to-partner and partner-to-PAQR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by PAQR8-low versus PAQR8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAQR8→partner) and Y-score (partner→PAQR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AVP →	+0.056	+3.632	<.001	.003	3	2
BLOOD_Leukemia	HAO2 →	+0.049	+3.556	<.001	.001	3	1
BLOOD_Leukemia	IL22 →	+0.021	+4.247	<.001	.004	3	1
BLOOD_Leukemia	GJA10 →	+0.030	+3.536	<.001	.001	3	1
BLOOD_Leukemia	NXPE4 →	+0.016	+3.106	<.001	.005	3	1
BLOOD_Leukemia	ASZ1 →	+0.080	+2.982	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

AVP by PAQR8 expression — LARGE_INTESTINE

Explore this box plot interactively →