PAQR4

Across TCGA pan-cancer cohorts, PAQR4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PAQR4 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PAQR4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PAQR4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

HNSC, CCRCC, and GBM are the cancer types where PAQR4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.324	0.866	.007	36	view →
CCRCC	OS	Tertile	All	1.000	0.437	.012	18	view →
GBM	DFS	Quartile	All	0.151	0.501	.030	4	view →
LSCC	DFS	Quartile	II,III,IV	0.147	0.815	.042	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PAQR4–HNSC (DFS)

Open the HNSC breakdown →