PAQR4

Across TCGA pan-cancer cohorts, PAQR4 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of PAQR4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PAQR4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PAQR4 is over-expressed in tumor.

COAD, HNSC, and KIRC are the cancer types where PAQR4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAQR4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+2.825	<.001	12	view →
HNSC	Female	III,IV	+1.497	<.001	12	view →
KIRC	Male	All	+1.426	<.001	12	view →
KIRP	Male	II,III,IV	+3.010	<.001	11	view →
BLCA	Male	All	+2.159	<.001	11	view →
THCA	Female	III,IV	+1.264	<.001	11	view →
STAD	Female	All	+2.274	<.001	9	view →
LIHC	Female	II,III,IV	+1.798	<.001	9	view →
KICH	All	II,III,IV	+1.757	<.001	9	view →
LUAD	All	III,IV	+1.565	<.001	9	view →
LUSC	Female	All	+1.890	<.001	7	view →
READ	All	All	+1.766	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

PAQR4–COAD

Open the COAD breakdown →