PAQR3

Across TCGA cell cohorts, PAQR3 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PAQR3-associated genes across cancer lineages are PRSS54, SPHKAP, and OR1M1. Each is linked with PAQR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAQR3-to-partner and partner-to-PAQR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS54 grouped by PAQR3-low versus PAQR3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAQR3→partner) and Y-score (partner→PAQR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRSS54 →	+0.036	+5.539	<.001	.003	3	1
BLOOD_Leukemia	SPHKAP →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	OR1M1 →	+0.019	+5.969	<.001	.001	3	1
BLOOD_Leukemia	OR9I1 →	+0.013	+5.539	<.001	.003	3	1
BLOOD_Leukemia	OR1D2 →	+0.019	+5.539	<.001	.003	3	1
BLOOD_Leukemia	SPPL2C →	+0.006	+4.922	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

PRSS54 by PAQR3 expression — BLOOD_Leukemia

Explore this box plot interactively →