PAQR3

Across TCGA cell cohorts, PAQR3 mutation is significantly associated with the mutation status of many other genes, with 2,093 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAQR3-associated genes across cancer lineages are HOXB8, HOXC11, and LCP1. Each is linked with PAQR3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAQR3-to-partner and partner-to-PAQR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HOXB8 grouped by PAQR3-low versus PAQR3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAQR3→partner) and Y-score (partner→PAQR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HOXB8 →	+5.329	+4.672	<.001	<.001	1	3
LARGE_INTESTINE	HOXC11 →	+3.007	+3.584	.008	.008	1	3
LARGE_INTESTINE	LCP1 →	+2.574	+4.182	.003	.003	1	3
LARGE_INTESTINE	SLC7A1 →	+3.744	+5.000	<.001	<.001	1	3
LARGE_INTESTINE	RNF217 →	+3.159	+4.632	<.001	<.001	1	3
LARGE_INTESTINE	CDK19 →	+3.007	+3.584	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,093 associations by consensus.

HOXB8 by PAQR3 expression — LARGE_INTESTINE

Explore this box plot interactively →