PAPSS1

Across TCGA patient cohorts, PAPSS1 protein abundance is significantly associated with the protein abundance of many other proteins, with 22,062 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PAPSS1-associated proteins across cancer lineages are RANGAP1, USO1, and PRRC1. Each is linked with PAPSS1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PAPSS1-to-partner and partner-to-PAPSS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAPSS1 versus RANGAP1 in BRCA, with a Pearson correlation of 0.41.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPSS1→partner) and Y-score (partner→PAPSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RANGAP1 →	+0.311	+0.467	<.001	<.001	3	6
OV	USO1 →	+0.310	+0.297	<.001	.003	3	5
COAD	PRRC1 →	+0.394	+0.254	<.001	<.001	3	5
HNSC	COPE →	+0.288	+0.284	<.001	<.001	3	5
UCEC	GFPT1 →	+0.454	+0.334	<.001	<.001	3	5
BRCA	RNF170 →	-0.619	-0.473	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,062 associations by consensus.

PAPSS1 vs RANGAP1 — BRCA

Explore this scatter interactively →