PAPPA

Across TCGA pan-cancer cohorts, PAPPA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PAPPA data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PAPPA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PAPPA expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where PAPPA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.235	0.887	.005	22	view →
LSCC	DFS	Median	II,III,IV	0.834	1.000	.004	18	view →
LUAD	DFS	Quartile	III,IV	0.199	0.854	.006	18	view →
PDAC	OS	Median	III,IV	0.877	0.610	.021	5	view →
HNSC	DFS	Median	III,IV	0.992	0.913	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PAPPA–CCRCC (DFS)

Open the CCRCC breakdown →