PAPPA

Across TCGA pan-cancer cohorts, PAPPA RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PAPPA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PAPPA RNA is repressed in tumor relative to normal tissue. In most cancer types PAPPA is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and UCEC are the cancer types where PAPPA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAPPA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.905	<.001	12	view →
KICH	All	IV	−3.967	<.001	11	view →
UCEC	All	All	−1.535	<.001	6	view →
LUSC	All	II,III,IV	+0.679	.016	4	view →
HNSC	All	All	+0.640	.002	4	view →
THCA	All	All	+0.253	.023	4	view →
CHOL	Female	All	+0.500	.006	2	view →
LUAD	All	All	+0.394	.007	2	view →
PRAD	All	All	−0.254	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PAPPA–KIRC

Open the KIRC breakdown →