PAPPA

Across TCGA patient cohorts, PAPPA protein abundance is significantly associated with the RNA expression of many other genes, with 11,641 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PAPPA-associated genes across cancer lineages are MYL9, GALNT15, and ABCA8. Each is linked with PAPPA in more than 7 cancer types. Because this analysis shows association rather than direction, both PAPPA-to-partner and partner-to-PAPPA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAPPA versus MYL9 in GBM, with a Pearson correlation of 0.66.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPPA→partner) and Y-score (partner→PAPPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MYL9 →	+1.399	+0.732	<.001	<.001	3	7
OV	GALNT15 →	+1.288	+0.671	<.001	.002	3	7
BRCA	ABCA8 →	+1.056	+0.564	<.001	<.001	3	7
OV	ZCCHC24 →	+1.318	+0.658	<.001	.001	3	7
OV	PODN →	+1.439	+0.566	<.001	.001	3	7
OV	COL14A1 →	+1.826	+0.707	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,641 associations by consensus.

PAPPA vs MYL9 — GBM

Explore this scatter interactively →