PAPPA

Across TCGA patient cohorts, PAPPA mutation is significantly associated with the RNA expression of many other genes, with 8,130 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAPPA-associated genes across cancer lineages are ZNF367, MELK, and GON7. Each is linked with PAPPA in more than 4 cancer types. Because this analysis shows association rather than direction, both PAPPA-to-partner and partner-to-PAPPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF367 grouped by PAPPA-low versus PAPPA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPPA→partner) and Y-score (partner→PAPPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF367 →	+0.787	+1.914	<.001	<.001	3	5
UCEC	MELK →	+0.809	+1.534	<.001	<.001	3	5
UCEC	GON7 →	+0.407	+1.831	<.001	<.001	3	5
UCEC	RPF2 →	+0.361	+1.436	<.001	<.001	3	5
UCEC	SKA2 →	+0.593	+1.924	<.001	<.001	3	5
UCEC	PSMD12 →	+0.384	+2.578	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,130 associations by consensus.

ZNF367 by PAPPA expression — UCEC

Explore this box plot interactively →