PAPPA

Across TCGA patient cohorts, PAPPA mutation is significantly associated with the total protein of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAPPA-associated genes across cancer lineages are ASNS, 4E-BP1, and ATM. Each is linked with PAPPA in more than 3 cancer types. Because this analysis shows association rather than direction, both PAPPA-to-partner and partner-to-PAPPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PAPPA-low versus PAPPA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPPA→partner) and Y-score (partner→PAPPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.564	+2.078	<.001	<.001	3	4
UCEC	4E-BP1 →	+0.368	+1.621	<.001	<.001	3	4
UCEC	ATM →	-0.355	-1.986	.001	.002	3	4
STAD	Caveolin-1 →	-0.789	-3.169	.007	.017	3	3
STAD	c-Kit →	-0.282	-2.115	.023	.017	3	3
COAD	Cyclin-E2 →	+0.144	+2.700	.048	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

ASNS by PAPPA expression — COAD

Explore this box plot interactively →