PAPPA

Across TCGA cell cohorts, PAPPA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,172 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PAPPA-associated GO terms across cancer lineages are Positive regulation of stress fiber assembly, Positive regulation of actin filament bundle assembly, and Positive regulation of supramolecular fiber organization. Each is linked with PAPPA in more than 12 cancer types. Because this analysis shows association rather than direction, both PAPPA-to-partner and partner-to-PAPPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of stress fiber assembly grouped by PAPPA-low versus PAPPA-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPPA→partner) and Y-score (partner→PAPPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Positive regulation of stress fiber assembly →	+0.113	+1.608	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Positive regulation of actin filament bundle assembly →	+0.127	+1.216	.009	.001	3	12
LIVER	Positive regulation of supramolecular fiber organization →	+0.101	+2.303	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Positive regulation of cytoskeleton organization →	+0.091	+1.776	.001	<.001	3	11
SOFT_TISSUE	Positive regulation of epithelial to mesenchymal transition →	+0.102	+2.391	.001	<.001	3	10
LUNG_NSCLC_LUSC	Regulation of plasminogen activation →	+0.271	+1.735	<.001	.006	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,172 associations by consensus.

Positive regulation of stress fiber assembly by PAPPA expression — SKIN

Explore this box plot interactively →