PAPPA

Across TCGA cell cohorts, PAPPA mutation is significantly associated with the RNA expression of many other genes, with 458 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAPPA-associated genes across cancer lineages are PDP2, PTCRA, and ATXN7L2. Each is linked with PAPPA in more than 2 cancer types. Because this analysis shows association rather than direction, both PAPPA-to-partner and partner-to-PAPPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDP2 grouped by PAPPA-low versus PAPPA-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPPA→partner) and Y-score (partner→PAPPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PDP2 →	+0.801	+3.299	.002	.004	3	3
PANCREAS	PTCRA →	+0.014	+4.029	<.001	.007	3	2
BLOOD_Leukemia	ATXN7L2 →	+0.481	+3.470	.003	.002	3	2
LARGE_INTESTINE	APBA3 →	+0.476	+3.321	.003	.003	3	2
LUNG_NSCLC_LUAD	OVGP1 →	+0.729	+3.074	.001	.008	3	2
LUNG_NSCLC_LUSC	KCNA1 →	+0.077	+3.584	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 458 associations by consensus.

PDP2 by PAPPA expression — BLOOD_Leukemia

Explore this box plot interactively →