PAPOLA

Across TCGA patient cohorts, PAPOLA mutation is significantly associated with the RNA expression of many other genes, with 3,345 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAPOLA-associated genes across cancer lineages are RN7SL201P, RNU6-1164P, and CCL5. Each is linked with PAPOLA in more than 1 cancer types. Because this analysis shows association rather than direction, both PAPOLA-to-partner and partner-to-PAPOLA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL201P grouped by PAPOLA-low versus PAPOLA-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPOLA→partner) and Y-score (partner→PAPOLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL201P →	+0.153	+5.569	<.001	.002	3	2
BLCA	RNU6-1164P →	+0.284	+3.187	.002	.002	3	2
UCEC	CCL5 →	+1.060	+2.065	<.001	<.001	3	2
UCEC	LINC02084 →	+0.261	+2.102	.008	<.001	3	2
UCEC	RN7SL248P →	+0.039	+2.513	<.001	.004	3	2
LUSC	RNVU1-28 →	+0.582	+4.475	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,345 associations by consensus.

RN7SL201P by PAPOLA expression — CESC

Explore this box plot interactively →