PAPLN

Across TCGA patient cohorts, PAPLN protein abundance is significantly associated with the RNA expression of many other genes, with 16,637 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PAPLN-associated genes across cancer lineages are C7, ABCA8, and EMCN. Each is linked with PAPLN in more than 7 cancer types. Because this analysis shows association rather than direction, both PAPLN-to-partner and partner-to-PAPLN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAPLN versus C7 in LSCC, with a Pearson correlation of 0.80.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPLN→partner) and Y-score (partner→PAPLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C7 →	+2.156	+0.553	<.001	<.001	3	8
BRCA	ABCA8 →	+1.235	+0.603	<.001	<.001	3	8
UCEC	EMCN →	+1.228	+0.675	<.001	<.001	3	8
BRCA	CHRDL1 →	+1.779	+0.578	<.001	<.001	3	7
HNSC	MRPL37 →	-0.595	-0.355	<.001	.001	3	7
BRCA	FLT3 →	+0.964	+0.419	.003	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,637 associations by consensus.

PAPLN vs C7 — LSCC

Explore this scatter interactively →