PAPLN

Across TCGA pan-cancer cohorts, PAPLN RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PAPLN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PAPLN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PAPLN is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, KICH, and THCA are the cancer types where PAPLN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAPLN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.850	<.001	11	view →
KICH	Female	All	−3.643	<.001	8	view →
THCA	Male	II,III,IV	+1.058	<.001	7	view →
UCEC	All	All	−1.589	<.001	6	view →
BRCA	All	III,IV	−0.874	<.001	6	view →
LUAD	All	All	+0.418	.002	5	view →
LIHC	Female	All	+0.975	.007	4	view →
CHOL	Female	All	+4.470	<.001	2	view →
KIRC	All	All	+0.370	.011	2	view →
PRAD	All	All	−0.320	.031	2	view →
STAD	Female	III,IV	+1.830	.045	1	view →
READ	Female	All	−0.888	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PAPLN–HNSC

Open the HNSC breakdown →