PAPLN

Across TCGA patient cohorts, PAPLN mutation is significantly associated with the RNA expression of many other genes, with 4,888 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAPLN-associated genes across cancer lineages are UBR7, SLBP, and GSKIP. Each is linked with PAPLN in more than 4 cancer types. Because this analysis shows association rather than direction, both PAPLN-to-partner and partner-to-PAPLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBR7 grouped by PAPLN-low versus PAPLN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPLN→partner) and Y-score (partner→PAPLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBR7 →	+0.581	+4.545	<.001	<.001	3	5
UCEC	SLBP →	+0.552	+1.917	<.001	<.001	3	5
COAD	GSKIP →	+0.924	+3.807	<.001	<.001	3	4
COAD	DCTN6 →	+0.432	+2.415	.005	.003	3	4
COAD	BCAS2 →	+0.367	+2.539	.006	.008	3	4
UCEC	EIF2S1 →	+0.548	+2.595	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,888 associations by consensus.

UBR7 by PAPLN expression — UCEC

Explore this box plot interactively →