PAPLN

Across TCGA patient cohorts, PAPLN mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAPLN-associated genes across cancer lineages are TIGAR, Caspase-7-cleavedD198, and eEF2. Each is linked with PAPLN in more than 2 cancer types. Because this analysis shows association rather than direction, both PAPLN-to-partner and partner-to-PAPLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by PAPLN-low versus PAPLN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPLN→partner) and Y-score (partner→PAPLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.151	+1.804	.001	.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.553	+1.827	.003	.015	3	3
STAD	eEF2 →	+0.366	+3.000	.019	.036	3	2
STAD	beta-Catenin →	+1.180	+3.000	.001	.036	3	2
UCEC	Chk2_pT68 →	-0.157	-3.433	.008	.005	3	2
UCEC	eIF4E →	+0.169	+2.000	.012	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

TIGAR by PAPLN expression — UCEC

Explore this box plot interactively →