PAPLN

Across TCGA cell cohorts, PAPLN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,011 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PAPLN-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Regulation of proteasomal protein catabolic process, and Negative regulation of myoblast fusion. Each is linked with PAPLN in more than 13 cancer types. Because this analysis shows association rather than direction, both PAPLN-to-partner and partner-to-PAPLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by PAPLN-low versus PAPLN-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPLN→partner) and Y-score (partner→PAPLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.130	+1.538	<.001	<.001	3	14
BONE	Regulation of proteasomal protein catabolic process →	+0.053	+1.010	.004	.004	3	14
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.134	+1.538	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.069	+1.680	.002	.002	3	12
LUNG_NSCLC_LUSC	Vacuolar transport →	+0.043	+0.979	<.001	.003	3	12
BONE	Regulation of ubiquitin-dependent protein catabolic process →	+0.067	+1.089	<.001	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,011 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by PAPLN expression — OESOPHAGUS

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