PAPLN

Across TCGA cell cohorts, PAPLN mutation is significantly associated with the RNA expression of many other genes, with 1,455 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAPLN-associated genes across cancer lineages are LINGO4, TTC33, and ASCC1. Each is linked with PAPLN in more than 2 cancer types. Because this analysis shows association rather than direction, both PAPLN-to-partner and partner-to-PAPLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINGO4 grouped by PAPLN-low versus PAPLN-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPLN→partner) and Y-score (partner→PAPLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LINGO4 →	+0.127	+2.896	.009	.004	3	3
LARGE_INTESTINE	TTC33 →	+0.659	+3.043	<.001	<.001	3	3
LARGE_INTESTINE	ASCC1 →	+0.478	+1.850	.007	.006	3	3
BLOOD_Leukemia	PRH2 →	+0.156	+3.517	<.001	.005	3	2
BLOOD_Leukemia	FBXW10 →	+0.032	+3.630	.004	.002	3	2
BLOOD_Leukemia	ADAM7 →	+0.012	+2.922	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,455 associations by consensus.

LINGO4 by PAPLN expression — BLOOD_Leukemia

Explore this box plot interactively →