PANX2

Across TCGA patient cohorts, PANX2 mutation is significantly associated with the RNA expression of many other genes, with 816 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PANX2-associated genes across cancer lineages are RNU1-4, IFNWP9, and RNU1-57P. Each is linked with PANX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PANX2-to-partner and partner-to-PANX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-4 grouped by PANX2-low versus PANX2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANX2→partner) and Y-score (partner→PANX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU1-4 →	+0.149	+4.837	<.001	.003	3	3
COAD	IFNWP9 →	+0.091	+5.568	<.001	<.001	3	3
READ	RNU1-57P →	+0.354	+5.421	<.001	.005	3	2
READ	SCARNA21B →	+0.384	+5.039	<.001	.008	3	2
CESC	RN7SL316P →	+0.394	+3.691	<.001	.003	3	2
CESC	PWRN4 →	+0.115	+4.569	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 816 associations by consensus.

RNU1-4 by PANX2 expression — CESC

Explore this box plot interactively →