PANK2

Across TCGA pan-cancer cohorts, PANK2 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PANK2 data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PANK2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PANK2 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

COAD, BLCA, and PRAD are the cancer types where PANK2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.183	0.786	<.001	60	view →
BLCA	OS	Median	II,III,IV	1.000	0.408	.015	13	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PANK2–COAD (DFS)

Open the COAD breakdown →