PANK2

Across TCGA pan-cancer cohorts, PANK2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PANK2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PANK2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PANK2 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, LIHC, and STAD are the cancer types where PANK2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PANK2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.489	<.001	10	view →
LIHC	Female	II,III,IV	+0.770	<.001	9	view →
STAD	All	II,III,IV	+0.653	<.001	9	view →
BLCA	All	All	+0.336	.002	8	view →
COAD	All	All	+0.232	.004	8	view →
KICH	Female	II,III,IV	−1.242	<.001	7	view →
LUSC	All	All	+0.433	<.001	6	view →
CHOL	Male	All	+1.593	<.001	5	view →
READ	Male	All	+0.686	.017	5	view →
BRCA	All	III,IV	+0.273	.023	4	view →
KIRP	Male	All	−0.381	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PANK2–HNSC

Open the HNSC breakdown →