PANK2

Across TCGA pan-cancer cohorts, PANK2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PANK2 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PANK2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PANK2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where PANK2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.295	0.827	.010	14	view →
PDAC	DFS	Median	IV	0.199	0.680	.004	9	view →
HNSC	DFS	Quartile	III,IV	0.891	0.573	.006	5	view →
GBM	DFS	Quartile	All	0.483	0.252	.037	3	view →
LUAD	OS	Median	III,IV	0.267	0.707	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PANK2–CCRCC (DFS)

Open the CCRCC breakdown →