PANK2

Across TCGA patient cohorts, PANK2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PANK2-associated genes across cancer lineages are p62 Lck ligand, PCNA, and S6_pS240_S244. Each is linked with PANK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PANK2-to-partner and partner-to-PANK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by PANK2-low versus PANK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANK2→partner) and Y-score (partner→PANK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.362	+3.179	.016	.010	3	1
UCEC	PCNA →	+0.344	+3.700	<.001	.001	3	1
UCEC	S6_pS240_S244 →	+0.372	+2.584	.049	.011	3	1
UCEC	Caspase-8 →	-0.287	-3.295	.014	.009	3	1
UCEC	eIF4E →	+0.201	+2.584	.040	.011	2	1
UCEC	FoxM1 →	+0.317	+3.331	.008	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

p62 Lck ligand by PANK2 expression — UCEC

Explore this box plot interactively →