PANK2

Across TCGA cell cohorts, PANK2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PANK2-associated genes across cancer lineages are OR52B2, ZSCAN1, and SLC18A3. Each is linked with PANK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PANK2-to-partner and partner-to-PANK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52B2 grouped by PANK2-low versus PANK2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANK2→partner) and Y-score (partner→PANK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR52B2 →	+0.022	+3.714	.001	.006	3	2
PANCREAS	ZSCAN1 →	+0.039	+5.000	<.001	.006	3	1
PANCREAS	SLC18A3 →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	TBL1Y →	+0.006	+5.614	<.001	.002	3	1
LARGE_INTESTINE	BMP10 →	+0.025	+3.882	<.001	.001	3	1
LARGE_INTESTINE	HTR1E →	+0.070	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OR52B2 by PANK2 expression — BLOOD_Lymphoma

Explore this box plot interactively →