PANK1

Across TCGA patient cohorts, PANK1 protein abundance is significantly associated with the RNA expression of many other genes, with 4,508 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PANK1-associated genes across cancer lineages are CYP1B1, PIK3R6, and PLEKHH1. Each is linked with PANK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PANK1-to-partner and partner-to-PANK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PANK1 versus CYP1B1 in CCRCC, with a Pearson correlation of -0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANK1→partner) and Y-score (partner→PANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CYP1B1 →	-1.457	-0.462	.001	<.001	3	3
LSCC	PIK3R6 →	-0.712	-0.565	.001	.001	3	3
GBM	PLEKHH1 →	+0.680	+0.295	<.001	.001	3	3
OV	ADAP1 →	+0.731	+0.485	.006	.007	3	2
OV	DIRAS2 →	+1.476	+0.689	<.001	.004	3	2
GBM	SLITRK5 →	+0.963	+0.420	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,508 associations by consensus.

PANK1 vs CYP1B1 — CCRCC

Explore this scatter interactively →