PANK1

Across TCGA pan-cancer cohorts, PANK1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PANK1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where PANK1 RNA is repressed in tumor relative to normal tissue. In most cancer types PANK1 is over-expressed in tumor, although a few such as KIRP and THCA show the opposite, repressed pattern.

KIRP, BLCA, and THCA are the cancer types where PANK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PANK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	III,IV	−1.867	<.001	11	view →
BLCA	Male	III,IV	+1.507	<.001	11	view →
THCA	Male	III,IV	−1.287	<.001	10	view →
KICH	Male	II,III,IV	−1.481	<.001	9	view →
KIRC	Male	IV	−1.312	<.001	9	view →
LIHC	Female	All	−0.945	<.001	8	view →
HNSC	All	All	−0.333	.015	7	view →
UCEC	All	All	+0.816	<.001	6	view →
LUSC	All	All	+0.436	<.001	6	view →
CHOL	All	All	−1.769	<.001	5	view →
STAD	All	II,III,IV	+0.611	.005	4	view →
BRCA	All	II,III,IV	+0.341	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PANK1–KIRP

Open the KIRP breakdown →